Tacrolimus monohydrate 109581-93-3 Kwayoyin cuta
Biya:T/T, L/C
Asalin samfur:China
Tashar Jirgin Ruwa:Beijing/Shanghai/Hangzhou
Ƙarfin samarwa:1kg/wata
Oda (MOQ):1 g
Lokacin Jagora:3 Ranakun Aiki
Yanayin ajiya:Ajiye a wuri mai sanyi, busasshiyar wuri, zazzabin ɗaki.
Kunshin kayan:kwalba, kwalba
Girman kunshin:1g / gwangwani, 5/kwali, 10g/kwali, 50g / kwalban, 500g / kwalban
Bayanin aminci:UN 2811 6.1/PG 3
Gabatarwa
Tacrolimus, maganin rigakafi ne na rigakafi.Bayan dasawa gabobin allogeneic, haɗarin ƙin yarda da gabobin yana da matsakaici.Don rage haɗarin kin amincewa da gabobin jiki, ana ba da tacrolimus.Hakanan za'a iya siyar da miyagun ƙwayoyi azaman magani na cikin gida a cikin maganin cututtukan da ke cikin T-cell kamar eczema da psoriasis.Ana iya amfani da shi don magance busassun ciwon ido a cikin kuliyoyi da karnuka.
Tacrolimus yana hana calcineurin, wanda ke da hannu wajen samar da interleukin-2, kwayoyin halitta wanda ke inganta ci gaba da yaduwar kwayoyin T, a matsayin wani ɓangare na amsawar da aka koya (ko daidaitawa) na jiki.
Musamman (USP43)
| Abu | Ƙayyadaddun bayanai |
| Bayyanar | Fari ko kusan fari crystalline foda |
| Ganewa | IR, HPLC |
| Solubility | Mai narkewa sosai a cikin methanol, mai narkewa cikin yardar kaina a cikin N, N dimethylformamide kuma cikin barasa, kusan a cikin ruwa mai narkewa. |
| Ragowa akan kunnawa | ≤0.10% |
| Najasa na halitta (tsari-2) | Ascomycin 19-epimer ≤0.10% |
| Ascomycin ≤0.50 % | |
| Desmethyl tacrolimus ≤0.10% | |
| Tacrolimus 8-epimer ≤0.15% | |
| Tacrolimus 8-propyl analog ≤0.15% | |
| Rashin tsabta wanda ba a sani ba -I ≤0.10 % | |
| Rashin ƙazantar da ba a sani ba -II ≤0.10 % | |
| Rashin tsabta wanda ba a sani ba -III ≤0.10 % | |
| Jimlar ƙazanta ≤1.00 % | |
| Jujjuyawar gani (kamar yadda aka saba) (10mg/ml a cikin N, Ndimethylformamide) | -110.0° ~ -115.0° |
| Abun ciki na ruwa (na KF) | ≤4.0% |
| Ragowar kaushi (na GC) | Acetone ≤1000ppm (A cikin gida) |
| Di-isopropyl ether ≤100ppm (A cikin gida) | |
| Ethyl ether ≤5000ppm | |
| Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| Gwajin ƙwayoyin cuta (a cikin gida) | Jimlar ƙididdiga ƙananan ƙwayoyin cuta na aerobic ≤100cfu/gm |
| Jimlar yisti da mold ƙidaya ≤10cfu/gm | |
| Ƙayyadaddun kwayoyin halitta (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) ya kamata ba ya nan. | |
| Assay (ta HPLC) (akan anhydrous da sauran ƙarfi kyauta) | 98% ~ 102% |
