Orlistat 96829-58-2 Kariyar Abincin Kiba
Biya:T/T, L/C
Asalin samfur:China
Tashar Jirgin Ruwa:Beijing/Shanghai/Hangzhou
Ƙarfin samarwa:800kg/wata
Oda (MOQ):25kg
Lokacin Jagora:3 Ranakun Aiki
Yanayin ajiya:Ajiye a wuri mai sanyi, busasshiyar wuri, zazzabin ɗaki.
Kunshin kayan:ganga
Girman kunshin:25kg/drum
Bayanin aminci:Ba kayan haɗari ba
Gabatarwa
Orlistat wani dogon aiki ne kuma mai ƙarfi takamaiman mai hana lipase na ciki.Fari ne ko kusan fari a zafin jiki, wanda ba ya narkewa a cikin ruwa, mai narkewa a cikin chloroform, kuma cikin sauƙi a cikin ethanol.Yana hana enzyme ta hanyar samar da haɗin gwiwa tare da rukunin serine masu aiki na lipase na ciki da pancreatic lipase a cikin ciki da ƙananan hanji.
Orlistat wani nau'i ne na maganin asarar nauyi mai hana lipase.Yana da wani hydrated wanda aka samu na lipstatin, wanda zai iya rage sha mai abinci da kuma rage nauyi.Wannan samfurin yana da ƙarfi da zaɓin hanawa na lipase na ciki da lipase pancreatic, ba shi da tasiri akan sauran enzymes masu narkewa (amylase, trypsin, chymotrypsin) da phospholipase, kuma baya shafar sha na carbohydrates, sunadarai da phospholipids.Yana hana enzyme musamman ta hanyar haɗin haɗin gwiwa tare da ragowar serine a wuraren aiki na lipase na ciki da pancreatic lipase a cikin sashin gastrointestinal, yana hana hydrolysis na triacylglycerol, yana rage cin monoglyceride da fatty acid kyauta, don haka yana sarrafa nauyin jiki.Ba a sha maganin miyagun ƙwayoyi ta hanyar gastrointestinal tract, kuma hanawa na lipase yana iya juyawa.
Wannan samfurin kuma yana da aikin daidaita lipids na jini.Yana iya rage triglyceride da ƙananan ƙarancin lipoprotein cholesterol a cikin jinin marasa lafiya masu kiba kuma yana ƙara yawan adadin lipoprotein mai girma zuwa ƙananan ƙarancin lipoprotein.
Lokacin da orlistat ya haɗu tare da ƙarancin kalori mai ƙarancin kalori, ya dace da dogon lokaci na jiyya na masu kiba da masu kiba, gami da waɗanda suka haɓaka abubuwan haɗari masu alaƙa da kiba.Yana da aikin sarrafa nauyi na dogon lokaci kamar asarar nauyi, kiyaye nauyi da sake dawowa rigakafi.Likitan ya nuna a fili cewa aikin sarrafa nauyin nauyi yana da matukar amfani don amfani na dogon lokaci lokacin kamfani tare da abinci ko bayan sa'a ɗaya na abinci.
Orlistat na iya rage yawan abubuwan haɗari masu alaƙa da kiba da sauran cututtukan da ke da alaƙa da kiba, gami da hypercholesterolemia, nau'in ciwon sukari na II, rashin haƙuri na glucose, hyperinsulinemia, hauhawar jini, da rage kitse a cikin gabobin.
Musamman (USP42)
| Abu | Ƙayyadaddun bayanai |
| Ganewa | HPLC, IR |
| Takamaiman jujjuyawar gani | -48.0°~-51.0° |
| Abun ciki na ruwa | ≤0.2% |
| Abubuwan da ke da alaƙa I | Abubuwan da ke da alaƙa da Orlistat A ≤0.2% |
| Abubuwan da suka danganci II | Abun da ke da alaƙa da Orlistat B ≤0.05% |
| Abubuwan da suka shafi III
| Formylleucine ≤0.2% |
| Abubuwan da ke da alaƙa da Orlistat C ≤0.05% | |
| Orlistat buɗaɗɗen zobe epimer ≤0.2% | |
| D-Leucine orlistat ≤0.2% | |
| Najasa wanda ba a tantance shi ba ≤0.1% | |
| Abubuwan da suka danganci IV | Abubuwan da ke da alaƙa da Orlistat D ≤0.2% |
| Orlistat bude zobe amide ≤0.1% | |
| Abubuwan da suka danganci V | Abubuwan da ke da alaƙa da Orlistat E ≤0.2% |
| Jimlar ƙazanta (I zuwa V) | ≤1.0% |
| Ragowar kaushi | Methanol ≤0.3% |
| EtOAc ≤0.5% | |
| n-Heptane ≤0.5% | |
| Ragowa akan kunnawa | ≤0.1% |
| Karfe masu nauyi kamar Pb | ≤20ppm |
| Rahoton da aka ƙayyade na HPLC | 98.0% ~ 101.5% (akan anhydrous, tushen ƙarfi) |
